RXFP3/4 agonist 2

Names

[ Name ]:
RXFP3/4 agonist 2

Biological Activity

[Description]:

RXFP3/4 agonist 2 is a potent, nonpeptide dual RXFP3/4 agonist (EC50=3.1 and 2.7 nM). RXFP3/4 agonist 2 also potently promotes interactions between RXFP3 and β-arrestin-2 with EC50 values in the range of 10-22 nM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Guan D, et al. Indole-Containing Amidinohydrazones as Nonpeptide, Dual RXFP3/4 Agonists: Synthesis, Structure-Activity Relationship, and Molecular Modeling Studies. J Med Chem. 2021;64(24):17866-17886.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₂N₆O₂

[ Molecular Weight ]:
402.45

Related Compounds

RXFP3/4 agonist 1
CB1 inverse agonist 2
Benzamide,4-[[[(2-chloroethyl)amino]carbonyl]amino]-N,N-dimethyl-
Ethyl 4-(2-bromophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
N-(4-{2-[(3-Chlorobenzyl)amino]ethyl}phenyl)-2-thiophenecarboximi damide dihydrochloride
trisodium 4-[[2,6-dihydroxy-3-[(4-nitrophenyl)azo]-5-[(4-sulphonato-1-naphthyl)azo]phenyl]azo]-5-hydroxynaphtalene-2,7-disulphonate
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine