Chitin synthase inhibitor 4

Chitin synthase inhibitor 4 (compound 4fh) is a chitin synthase (CHS) inhibitor with fungicidal effect. Chitin synthase inhibitor 4 is a potential CHS-based fungicide in agriculture[1].

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Chitin synthase inhibitor 4 shows good antifungal activities against V. mali and S. sclerotiorum with EC50 values of 0.71 and 2.47 μg/mL, respectively[1]. Chitin synthase inhibitor 4 (50 μg/mL) displays potency inhibition against V. mali and S. sclerotiorum with inhibition rates of 90.3% and 88.7%, respectively[1]. Chitin synthase inhibitor 4 (1 μg/mL) blocks the hyphae growth, results abnormal growth, with inducing cell content decreasing, cell wall degradation, and plasmolysis[1]. Chitin synthase inhibitor 4 (50 μM; 3 h) exhibits inhibition against chitin synthase (CHS) and polyoxin D with inhibition rates of 68.08% and 63.84%, respectively[1].

Chitin synthase inhibitor 4 (50 μg/mL) has considerable curative and protective effects against S. sclerotiorum vivo, and no obvious phytotoxicity [1]. Chitin synthase inhibitor 4 has low acute toxicity, with no carcinogenic and mutagenic toxicity risk[1]. Animal Model: Rat with Salmonella typhimurium[1] Dosage: As Acute Oral Toxicity for Chemicals-Acute Toxic Class Method Administration: Oral gavage Result: Showed acute toxicity of 3.58 as toxicity grading standard, and negative carcinogenic toxicity, negative mutagenic toxicity.

[1]. Zhang X, et al. Synthesis, Antifungal Activity, and 3D-QASR of Novel 1,2,3,4-Tetrahydroquinoline Derivatives Containing a Pyrimidine Ether Scaffold as Chitin Synthase Inhibitors. J Agric Food Chem. 2022 Jul 21.