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c-Met-IN-9

Names

[ CAS No. ]:
2760326-29-0

[ Name ]:
c-Met-IN-9

Biological Activity

[Description]:

c-Met-IN-9, a 4-phenoxypyridine derivative, is a c-Met kinas inhibitor with an IC50 of 12 nM. c-Met-IN-9 induces cells apoptosis, and has antitumor activities[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR

[Target]

c-Met:12 nM (IC50)


[In Vitro]

c-Met-IN-9 (Compound T14) shows remarkable antiproliferative activities against MKN-45, A549 and H460 cell lines with IC50 values of 0.64 μM, 1.92 μM and 2.68 μM, respectively[1]. c-Met-IN-9 could inhibit cells colony formation, induce cells apoptosis, and inhibit cells motility[1].

[References]

[1]. Ju Liu, et al. Novel 4-phenoxypyridine derivatives bearing imidazole-4-carboxamide and 1,2,4-triazole-3-carboxamide moieties: Design, synthesis and biological evaluation as potent antitumor agents. Bioorg Chem. 2022 Jan 19;120:105629.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H19F2N5O3

[ Molecular Weight ]:
475.45

Related Compounds