PDGFRα/FLT3-ITD-IN-1

Names

[ CAS No. ]:
2761259-05-4

[ Name ]:
PDGFRα/FLT3-ITD-IN-1

Biological Activity

[Description]:

PDGFRα/FLT3-ITD-IN-1 (Compound 12d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of more than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3

[References]

[1]. Vlková K, et al. Synthesis and biological activity evaluation of novel 2,6,9-trisubstituted purine conjugates as potential protein kinases inhibitors. Bioorg Med Chem Lett. 2022 Mar 15;60:128603

Chemical & Physical Properties

[ Molecular Formula ]:
C27H39N9O

[ Molecular Weight ]:
505.66

Related Compounds