β2AR agonist /M-receptor antagonist-1

Names

[ CAS No. ]:
2772700-36-2

[ Name ]:
β2AR agonist /M-receptor antagonist-1

Biological Activity

[Description]:

β2AR agonist /M-receptor antagonist-1 is a potent dual muscarinic antagonist/beta 2 agonist (MABA). β2AR agonist /M-receptor antagonist-1 potently relaxes either Carbachol (HY-B1208)-induced contraction, in the absence (MABA) or presence of Propranolol (M3; HY-B1208), or Histamine (HY-B1204)-induced contraction (β2)[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR
Signaling Pathways >> GPCR/G Protein >> mAChR
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Neurological Disease

[Target]

Beta-2 adrenergic receptor


[References]

[1]. Huihui Ti, et al. Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs). J Med Chem. 2019 Jul 11;62(13):5944-5978.  

[2]. Fiorella Pastore, et al.In vitro pharmacological characterization of the novel inhaled bronchodilator CHF6366 acting as dual muscarinic antagonist/β2-agonist (MABA). European Respiratory Journal 2017 50: PA1805.

Chemical & Physical Properties

[ Molecular Formula ]:
C33H40FN5O5S2

[ Molecular Weight ]:
669.83

Related Compounds