L-Glutamic acid-d5

Names

[ CAS No. ]:
2784-50-1

[ Name ]:
L-Glutamic acid-d5

[Synonym ]:
L-(2,3,3,4,4-H)Glutamic acid
glutamic acid-d5
2,3,3,4,4-pentadeuterio-L-glutamic acid
Glusate-d5
L-Glutamic-2,3,3,4,4-d acid
L-glutamic-2,3,3,4,4-d5 acid
Glutacid-d5
Glutamicol-d5
L-|A-Aminoglutaric Acid-d5
Glutaminol-d5
Glutaton-d5
Glutamidex-d5

Biological Activity

[Description]:

L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Signaling Pathways >> Apoptosis >> Apoptosis
Signaling Pathways >> Apoptosis >> Ferroptosis
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
333.8±32.0 °C at 760 mmHg

[ Melting Point ]:
205ºC (dec.)(lit.)

[ Molecular Formula ]:
C5H4D5NO4

[ Molecular Weight ]:
152.160

[ Flash Point ]:
155.7±25.1 °C

[ Exact Mass ]:
152.084549

[ PSA ]:
100.62000

[ LogP ]:
-1.43

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.522

[ Storage condition ]:
-20°C

Safety Information

[ WGK Germany ]:
3

Related Compounds