4,4',4"-Ethylidynetriphenol

Names

[ Name ]:
4,4',4"-Ethylidynetriphenol

[Synonym ]:
MFCD00012180
Phenol, 4,4',4''-ethylidynetris-
1,1,1-tri-(4-hydroxy-phenyl)-ethane
4,4',4''-(ethane-1,1,1-triyl)triphenol
4,4',4''-Ethane-1,1,1-triyltriphenol
tris(p-hydroxyphenyl)ethane
4,4',4"-(Ethylidene)trisphenol
Tris(4-hydroxyphenyl)ethane
1,1,1-Tris(p-hydroxyphenyl)ethane
4,4',4''-Ethylidynetrisphenol
EINECS 405-800-7
Phenol,4,4',4''-ethylidynetris
4,4',4"-Ethylidynetriphenol
4,4',4''-(1,1,1-Ethanetriyl)triphenol
QR DX1&R DQ&R D1
1,1,1-Tris(4-Hydroxyphenyl)Ethane

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
531.8±45.0 °C at 760 mmHg

[ Melting Point ]:
246-248 °C(lit.)

[ Molecular Formula ]:
C₂₀H₁₈O₃

[ Molecular Weight ]:
306.355

[ Flash Point ]:
251.0±23.3 °C

[ Exact Mass ]:
306.125580

[ PSA ]:
60.69000

[ LogP ]:
3.83

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.656

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL4375275

CHEMICAL NAME :: Phenol, 4,4',4''-ethylidynetris-

CAS REGISTRY NUMBER :: 27955-94-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530499-1 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Skin and Appendages - hair

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530499-1

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530499-1

Safety Information

[ Symbol ]:

GHS09

[ Hazard Statements ]:
H411

[ Precautionary Statements ]:
P273

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39-S61

[ RIDADR ]:
UN 3077 9/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
SL4375275

[ HS Code ]:
2907199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2907199090

[ Summary ]:
2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase.

J. Med. Chem. 52 , 2716-23, (2009)

Hepatitis C virus nonstructural protein 3 (HCV NS3) helicase is believed to be essential for viral replication and has become an attractive target for the development of antiviral drugs. A fluorescenc...