PBRM1-BD2-IN-8

Names

[ CAS No. ]:
2819989-75-6

[ Name ]:
PBRM1-BD2-IN-8

Biological Activity

[Description]:

PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor (PBRM1-BD2 Kd=4.4 μM, PBRM1-BD2 IC50=0.16 μM; PBRM1-BD5 Kd=25 μM). PBRM1-BD2-IN-8 shows anti-cancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

IC50: 0.16 μM (PBRM1-BD2)[1]

[In Vitro]

PBRM1-BD2-IN-8 (0-100 μM; 48 h) inhibits the growth of PBRM1-dependent prostate cancer cells[1]. Cell Viability Assay[1] Cell Line: LNCaP cells Concentration: 0-100 μM Incubation Time: 48 hours Result: Inhibited the growth of LNCaP cells with IC50 value of about 9 μM.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₃BrN₂O

[ Molecular Weight ]:
317.18

PBRM1-BD2-IN-8

Names

Biological Activity

Chemical & Physical Properties

Related Compounds