USP1-IN-3

Names

[ CAS No. ]:
2821749-58-8

[ Name ]:
USP1-IN-3

Biological Activity

[Description]:

USP1-IN-3 is a selective USPI inhibitor. USP1-IN-3 inhibits USPI-UAFI with an IC50 value of ＜30 nM. USP1-IN-3 can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

IC50: ＜30 nM (USPI-UAFI)[1]


[In Vitro]

USP1-IN-3 has inhibitory against USPI-UAFI with an IC50 value of ＜30 nM[1]. USP1-IN-3 has viability for a non-isogenic pair of BRCAI mutant and BRCAI WT cell lines with IC50 values of ＜100 nM and ＞ 10 μM, respectively[1].

[References]

[1]. Scott Throner, et al. Pyrrolo[3,2-d]pyrimidine compounds and methods of use in the treatment of cancer. Patent. WO2022174184A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H24F3N7O

[ Molecular Weight ]:
519.52

Related Compounds