benthiocarb

Names

[ Name ]:
benthiocarb

[Synonym ]:
Carbamothioic acid, N,N-diethyl-, S-[(4-chlorophenyl)methyl] ester
Saturno
EINECS 248-924-5
S-[(4-Chlorophenyl)methyl] Diethylcarbamothioate
S-4-chlorobenzyl N,N-diethylthiocarbamate
Saturn
S-[(4-chlorophenyl)methyl] N,N-diethylcarbamothioate
benthiocarb
Bencarb
Bolero
Siacarb
MFCD00055475
Thiobencarb
S-p-chlorobenzyl diethylthiocarbamate
S-4-Chlorobenzyl Diethyl(thiocarbamate)
Carbamothioic acid, diethyl-, S-[(4-chlorophenyl)methyl] ester
S-(p-Chlorobenzyl) diethylthiocarbamate (8CI)
S-(4-chlorobenzyl) diethylthiocarbamate
Bolero 8EC
Caswell No. 207DA
S-4-chlorobenzyl diethylthiocarbamate
S-(4-Chlorobenzyl) diethylcarbamothioate

Biological Activity

[Description]:

Thiobencarb is an herbicide, can reduce growth, photosynthetic activity, and amount of rieske iron-sulfur protein in the diatom Thalassiosira pseudonana[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Shimasaki Y, et al. Thiobencarb herbicide reduces growth, photosynthetic activity, and amount of Rieske iron-sulfur protein in the diatom Thalassiosira pseudonana. J Biochem Mol Toxicol. 2013 Sep;27(9):437-44.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
350.5±44.0 °C at 760 mmHg

[ Melting Point ]:
3.3ºC

[ Molecular Formula ]:
C₁₂H₁₆ClNOS

[ Molecular Weight ]:
257.78

[ Flash Point ]:
165.8±28.4 °C

[ Exact Mass ]:
257.064117

[ PSA ]:
45.61000

[ LogP ]:
3.53

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.563

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EZ7260000

CHEMICAL NAME :: Carbamic acid, diethylthio-, S-(p-chlorobenzyl) ester

CAS REGISTRY NUMBER :: 28249-77-6

LAST UPDATED :: 199706

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C12-H16-Cl-N-O-S

MOLECULAR WEIGHT :: 257.80

WISWESSER LINE NOTATION :: GR B1SVN2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 920 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >7700 mg/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - lacrimation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1338 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 673 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >7800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 300 ug/plate

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 45,990,1997 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H410

[ Precautionary Statements ]:
P273-P501

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R22;R50/53

[ Safety Phrases ]:
S60-S61

[ RIDADR ]:
UN 3082

[ WGK Germany ]:
3.0

[ RTECS ]:
EZ7260000

[ Hazard Class ]:
9.0

[ HS Code ]:
2930200011

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930200011

[ Summary ]:
2930200011 s,s'-(2-(dimethylamino)propane-1,3-diyl) dicarbamothioate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

Articles

Effect of thiobencarb and pretilachlor on microorganisms in relation to mineralization of C and N in the Gangetic alluvial soil of West Bengal.

Environ. Monit. Assess. 186(10) , 6849-56, (2014)

An experiment was conducted under laboratory conditions to investigate the effect of two pre-emergence herbicides, viz., thiobencarb (at 1.5 and 4.5 kg active ingredient (a.i.) ha(-1)) and pretilachlo...

Field dissipation and environmental hazard assessment of clomazone, molinate, and thiobencarb in Australian rice culture.

J. Agric. Food Chem. 54(19) , 7213-20, (2006)

The fates of clomazone [2-(2-chlorophenyl)methyl-4,4-dimethyl-3-isoxazolidinone], molinate (S-ethyl hexahydro-1-H-azepine-1-carbothioate), and thiobencarb {S-[(4-chlorophenyl)methyl]diethylcarbamothio...

QSAR study on permeability of hydrophobic compounds with artificial membranes.

Bioorg. Med. Chem. 15 , 3756-67, (2007)

We previously reported a classical quantitative structure-activity relationship (QSAR) equation for permeability coefficients (P(app-pampa)) by parallel artificial membrane permeation assay (PAMPA) of...