FK962

Names

[ Name ]:
FK962

[Synonym ]:
N-(1-Acetyl-4-piperidinyl)-4-fluorobenzamide
N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide
Benzamide, N-(1-acetyl-4-piperidinyl)-4-fluoro-
MFCD09832545

Biological Activity

[Description]:

FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

Somatostatin release[1]

[In Vitro]

FK962 (1 nM-1 μM) significantly enhances high K+-evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp[1].

[In Vivo]

FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease[2]. Animal Model: Male Lister Hooded rats, weighing approximately 270-300[2] Dosage: 0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg Administration: Administered i.p. Result: Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition.

[References]

[1]. Tokita K, et al. FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats. Eur J Pharmacol. 2005 Dec 19;527(1-3):111-20.

[2]. McCarthy AD, et al. FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease. Pharmacol Biochem Behav. 2011 Mar;98(1):76-80.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
474.4±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₇FN₂O₂

[ Molecular Weight ]:
264.295

[ Flash Point ]:
240.7±27.3 °C

[ Exact Mass ]:
264.127411

[ LogP ]:
1.59

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.557