5-Amino-2-methylphenol
Names
[ CAS No. ]:
2835-95-2
[ Name ]:
5-Amino-2-methylphenol
[Synonym ]:
EINECS 220-618-6
5-Amino-2-methylphenol
2-hydroxy-p-toluidine
5-AMINO-ORTHO-CRESOL
5-AMINO-2-CRESOL
2-methyl-5-amino-phenol
1-methyl-2-hydroxy-4-amino-benzene
Rodol PAOC
4-Amino-2-hydroxytoluene
JAROCOL 2M5AP
5-Amino-o-kresol
3-hydroxy-4-methyl-aniline
6-methyl-1-hydroxy-3-aminobenzene
5-Amino-O-Crosol
3-Hydroxy-4-methylaniline
Phenol, 5-amino-2-methyl-
3-Hydroxy-p-toluidine
MFCD00043922
3-amino-6-methyl-phenol
2-hydroxy-4-aminotoluene
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
268.6±20.0 °C at 760 mmHg
[ Melting Point ]:
160-162 °C(lit.)
[ Molecular Formula ]:
C7H9NO
[ Molecular Weight ]:
123.152
[ Flash Point ]:
116.3±21.8 °C
[ Exact Mass ]:
123.068413
[ PSA ]:
46.25000
[ LogP ]:
0.80
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.616
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SJ6090000
- CHEMICAL NAME :
- Phenol, 5-amino-2-methyl-
- CAS REGISTRY NUMBER :
- 2835-95-2
- BEILSTEIN REFERENCE NO. :
- 2802317
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C7-H9-N-O
- MOLECULAR WEIGHT :
- 123.17
- WISWESSER LINE NOTATION :
- ZR CQ D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3600 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - domestic
- DOSE/DURATION :
- 562 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 54 gm/kg/13W-C
- TOXIC EFFECTS :
- Endocrine - evidence of thyroid hypofunction Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 328 gm/kg/26W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Endocrine - changes in thyroid weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 333 ug/plate
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11(Suppl 12),1,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5756 No. of Facilities: 4579 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 44842 (estimated) No. of Female Employees: 35032 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36-S37/39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
SJ6090000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
2922299090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922299090
[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
J. Chem. Soc., Perkin Trans. II 5 , 539-548, (1972)