Anti-infective agent 6

Names

[ CAS No. ]:
2839192-35-5

[ Name ]:
Anti-infective agent 6

Biological Activity

[Description]:

Anti-infective agent 6 (compound 28) is a potent anti-infectious agent. Anti-infective agent 6 shows a good activity against P. falciparum F32-ART (IC50=1.4 μM) with a good selectivity index (SI>36). Anti-infective agent 6 also shows a potency against L. donovani (IC50=3.5 μM)[1].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

Anti-infective agent 6 (compound 28) is less cytotoxic with a CC50 value higher than 100 μM in macrophage RAW 264.7 cells and consequently a SI higher than 28 for Leishmania parasites[1].

[References]

[1]. Koumpoura CL, et al. Design of Anti-infectious Agents from Lawsone in a Three-Component Reaction with Aldehydes and Isocyanides. ACS Omega. 2022 Oct 3;7(40):35635-35655.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H15NO3

[ Molecular Weight ]:
257.28

Related Compounds