DCP-LA

Names

[ CAS No. ]:
28399-31-7

[ Name ]:
DCP-LA

[Synonym ]:
Clobenpropit dihydrobromide
DCP-LA

Biological Activity

[Description]:

DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Neurological Disease

Signaling Pathways >> TGF-beta/Smad >> PKC

[Target]

PKCε

[References]

[1]. Kanno T, et al. DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain. Cell Physiol Biochem. 2015;37(1):193-200.

Chemical & Physical Properties

[ Density]:
0.969g/cm3

[ Boiling Point ]:
417.047ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₆O₂

[ Molecular Weight ]:
308.50

[ Flash Point ]:
184.49ºC

[ Exact Mass ]:
308.27200

[ PSA ]:
37.30000

[ LogP ]:
6.04430

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.491

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site.

J. Lipid Res. 47 , 1146-1156, (2006)

This study examined the effect of 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA), a newly synthesized linoleic acid derivative with cyclopropane rings instead of cis-double bond...

Linoleic acid derivative DCP-LA improves learning impairment in SAMP8.

Neuroreport 17 , 105-108, (2006)

In the water-maze test, the linoleic acid derivative, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) (1 mg/kg, intraperitoneally), significantly shortened the prolonged latency ...