Werner syndrome RecQ helicase-IN-3
Names
[ CAS No. ]:
2869954-98-1
[ Name ]:
Werner syndrome RecQ helicase-IN-3
Biological Activity
[Description]:
Werner syndrome RecQ helicase-IN-3 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-3 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-3 shows anticancer activity[1].
[Related Catalog]:
[Target]
IC50: 0.06 µM (WRN)[1]
[In Vitro]
Werner syndrome RecQ helicase-IN-3 (example 96) (0-10 µM; 8-20 days) 显示抗增殖活性,对 SW48,DLD1 WRN-KO 细胞的 GI50s 值分别为 0.06,>10 µM[1]。 Cell Proliferation Assay[1] Cell Line: SW48, DLD1 WRN-KO cells Concentration: 0-10 µM Incubation Time: 8-20 days Result: Showed antiproliferative activity with GI50s of 0.06, >10 µM for SW48, DLD1 WRN-KO cells, respectively.
[In Vivo]
Werner syndrome RecQ helicase-IN-3 (120 mg/kg; daily for 22 days) 在小鼠体内显示出抗癌活性[1]。 Animal Model: Female Crl:NU(NCr)-Foxn1nu -Homozygous nude mice (SW48 xenografts cells)[1] Dosage: 120 mg/kg Administration: P.o.; daily for 22 days Result: Inhibited tumor growth.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C31H30ClF3N8O5
[ Molecular Weight ]:
687.07