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D-Mannitol-13C6

Names

[ CAS No. ]:
287112-34-9

[ Name ]:
D-Mannitol-13C6

Biological Activity

[Description]:

D-Mannitol-13C6 is the 13C labeled D-Mannitol[1]. D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator[2][3][4].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Tan, K., et al., The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem, 2009. 284(52): p. 36670-9.  

[3]. Nishiyama, A., et al., Mannitol lowers fat digestibility and body fat accumulation in both normal and cecectomized rats. J Nutr Sci Vitaminol (Tokyo), 2009. 55(3): p. 242-51.  

[4]. Hanieh, H. and E. Sakaguchi, Effect of D-mannitol on feed digestion and cecotrophic system in rabbits. Anim Sci J, 2009. 80(2): p. 157-62.  

Chemical & Physical Properties

[ Melting Point ]:
167-170ºC(lit.)

[ Molecular Formula ]:
C6H14O6

[ Molecular Weight ]:
188.12800

[ Exact Mass ]:
188.09900

[ PSA ]:
121.38000

Related Compounds