c-Myc inhibitor 7

Names

[ CAS No. ]:
2883535-99-5

[ Name ]:
c-Myc inhibitor 7

Biological Activity

[Description]:

c-Myc inhibitor 7 is a c-Myc inhibitor and a multiple target protein degrader. c-Myc inhibitor 7 effective degrades c-MYC, CK1α, GSPT1 and IKZF1/2/3 proteins in a variety of tumor cells. c-Myc inhibitor 7 can be used for c-Myc high expression related disease research, such as cancer, cardiovascular and cerebrovascular diseases, and viral infection[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Research Areas >> Infection
Signaling Pathways >> Apoptosis >> c-Myc
Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase
Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase

[In Vitro]

c-Myc inhibitor 7 (0-10 mM；3 天) 抑制 HL60 细胞增殖，IC50 值为 0.5 nM[1]。 c-Myc inhibitor 7 促进 60-90% HL60 细胞中蛋白的降解[1]。 c-Myc inhibitor 7 (1，3，10 和 100 nM；24 小时) 在多种细胞系中降解 c-Myc，CKla，GSPTl，IKZFl，IKZF2 和 IKZF3 蛋白[1]。

[References]

[1]. TONG YOUZHI, et al. 2,6-Dioxopiperidine compounds as c-Myc inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. WO2022268066. 2022.

Chemical & Physical Properties

[ Molecular Formula ]:
C35H30N6O5

[ Molecular Weight ]:
614.65

Related Compounds