SHR-1701

Names

[ CAS No. ]:
2891860-17-4

[ Name ]:
SHR-1701

Biological Activity

[Description]:

SHR-1701 (Retlirafusp alfa) is a bifunctional fusion protein targeting PD-L1 and TGF-β for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1

[In Vitro]

SHR-1701 (10 μg/mL)可以抑制 TGF-β 信号通路，激活 PI3K/Akt/Erk 信号通路，挽救淋巴细胞恢复受损的肺癌患者外周血CD8+ T 细胞的抗肿瘤功能[1]。

[References]

[1]. Bo Cheng, et al. Anti-PD-L1/TGF-βR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer. Cancer Commun (Lond). 2022 Jan;42(1):17-36.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds