Seleno-DL-cystine

Names

[ Name ]:
Seleno-DL-cystine

[Synonym ]:
seleno-dl-cystine
alanine,3,3'-diselenobis-

Biological Activity

[Description]:

Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: Anti-cancer[1]

[References]

[1]. Eva Ari Wahyuni, et al. Selenocystine induces oxidative-mediated DNA damage via impairing homologous recombination repair of DNA double-strand breaks in human hepatoma cells. Chem Biol Interact. 2022 Sep 25:365:110046.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₂N₂O₄Se₂

[ Molecular Weight ]:
334.09

[ Exact Mass ]:
335.91300

[ PSA ]:
126.64000

[ Vapour Pressure ]:
5.12E-13mmHg at 25°C

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H331-H373-H410

[ Precautionary Statements ]:
P261-P273-P301 + P310-P311-P501

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
23/25-33-50/53

[ Safety Phrases ]:
20/21-28-45-60-61

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3.0

[ RTECS ]:
AY6031000

[ HS Code ]:
2922499990

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Bioaccessibility of selenium, selenomethionine and selenocysteine from foods and influence of heat processing on the same.

Food Chem. 194 , 1293-9, (2015)

Selenium (Se) is an essential nutrient with diverse physiological functions. The selenium content of commonly consumed cereals, pulses and green leafy vegetables (GLV) was determined. Bioaccessibility...

Effects of selenium on development, survival, and accumulation in the honeybee (Apis mellifera L.).

Environ. Toxicol. Chem. 32(11) , 2584-92, (2013)

Apis mellifera L. (Hymenoptera: Apidae) is an important agricultural pollinator in the United States and throughout the world. In areas of selenium (Se) contamination, honeybees may be at risk because...

Selenocystine induces reactive oxygen species–mediated apoptosis in human cancer cells

Biomed. Pharmacother. 63(2) , 105-13, (2009)

Epidemiological and clinical studies have demonstrated that dietary supplementation of selenium (Se) could reduce the incidence of human cancers. In this study, selenocystine, a nutritionally availabl...