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1,3,5-Triazin-2(1H)-one,4-amino-1-(2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-

Names

[ CAS No. ]:
28998-36-9

[ Name ]:
1,3,5-Triazin-2(1H)-one,4-amino-1-(2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-

[Synonym ]:
5-Azacytidine,3',5'-tribenzoate
[(2R,3R,4R,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)-3,4-dibenzoyloxyoxolan-2-yl]methyl benzoate
2',3',5'-tri-O-benzoyl-5-azacytidine
s-Triazin-2(1H)-one,2',3',5'-tribenzoate

Biological Activity

[Description]:

2',3',5'-Tri-O-benzoyl-5-azacytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.  

Chemical & Physical Properties

[ Density]:
1.43g/cm3

[ Boiling Point ]:
709.9ºC at 760mmHg

[ Molecular Formula ]:
C29H24N4O8

[ Molecular Weight ]:
556.52

[ Flash Point ]:
383.1ºC

[ Exact Mass ]:
556.15900

[ PSA ]:
161.93000

[ LogP ]:
3.00730

[ Vapour Pressure ]:
5.31E-20mmHg at 25°C

[ Index of Refraction ]:
1.666

Precursor & DownStream

Precursor

DownStream