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Pinoresinol dimethyl ether

Names

[ CAS No. ]:
29106-36-3

[ Name ]:
Pinoresinol dimethyl ether

[Synonym ]:
(1S,3aR,4S,6aR)-1,4-Bis(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan
1H,3H-Furo[3,4-c]furan, 1,4-bis(3,4-dimethoxyphenyl)tetrahydro-, (1S,3aR,4S,6aR)-
(7S,7’S,8R,8’R)-eudesmin
(1S,3aR,4S,6aR)-1,4-bis(3,4-dimethoxyphenyl)-hexahydrofuro[3,4-c]furan
Pinoresinol dimethyl ether

Biological Activity

[Description]:

Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furofuran lignan isolated from the stem bark of Magnolia kobus with neuritogenic activity. Pinoresinol dimethyl ether ((+)-Eudesmin) can induce neuritis outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. TeruhisaMiyauchi, et al. Formation of (+)-eudesmin in Magnolia kobus DC. Var. borealis sarg. Phytochemistry, 1998, 47(4): 665-670.

[2]. Yang YJ, et al. Effects of (+)-eudesmin from the stem bark of magnolia kobus DC. var. borealis Sarg. on neurite outgrowth in PC12 cells. Arch Pharm Res. 2006 Dec;29(12):1114-8.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
517.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H26O6

[ Molecular Weight ]:
386.438

[ Flash Point ]:
209.8±30.0 °C

[ Exact Mass ]:
386.172943

[ LogP ]:
3.08

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.547

[ Storage condition ]:
-20℃

Related Compounds