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Ac-Pro-Gly-Pro-OH

Names

[ CAS No. ]:
292171-04-1

[ Name ]:
Ac-Pro-Gly-Pro-OH

[Synonym ]:
ABCB1
N-acetyl-proline-glycine-proline
AcPGP
MDR1 HUMAN MEMBRANE PREPARATION
PGP
Ac-PGP trifluoroacetate salt hydrate

Biological Activity

[Description]:

Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CXCR
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> CXCR

[Target]

CXCR2


[References]

[1]. Patel DF, et al The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease. Eur Respir Rev. 2018 Jun 27;27(148):180017.  

[2]. Kim SD, et al. Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis. Am J Respir Crit Care Med. 2011 Jul 15;184(2):243-51.  

Chemical & Physical Properties

[ Molecular Formula ]:
C14H21N3O5

[ Molecular Weight ]:
311.33

[ Exact Mass ]:
311.14800

[ PSA ]:
107.02000

MSDS

Click to get detail MSDS

Related Compounds