Butoxamin

Names

[ Name ]:
Butoxamin

[Synonym ]:
Butaxaminum
Butaxamina
Butaxamin
Butaxamine

Biological Activity

[Description]:

Butaxamine (Butoxamin) is a potent, selective and orally active β2-adrenoceptor antagonist. Butaxamine shows antiosteoporotic activity[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Metabolic Disease

[Target]

β2 adrenoceptor

[In Vivo]

Butaxamine (0.1, 1, 10 mg/kg; p.o.; once daily for 12 weeks) 增加大鼠的骨量指数以及强度和韧性的生物力学参数[1]。 Animal Model: Seven-week-old male SHR/Izm and WKY/Izm rats[1] Dosage: 0.1, 1, 10 mg/kg Administration: P.o.; once daily for 12 weeks Result: Prevented a decrease in bone mass and an increase in biomechanical fragility developing in SHR, suppressed both a decrease in bone formation and an increase in bone resorption in SHR.

[References]

[1]. Arai M, et al. Dose effects of butoxamine, a selective β2-adrenoceptor antagonist, on bone metabolism in spontaneously hypertensive rat. Eur J Pharmacol. 2013 Feb 15;701(1-3):7-13.

Chemical & Physical Properties

[ Density]:
1.027g/cm3

[ Boiling Point ]:
391ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₅NO₃

[ Molecular Weight ]:
267.36400

[ Flash Point ]:
190.3ºC

[ Exact Mass ]:
267.18300

[ PSA ]:
50.72000

[ LogP ]:
2.90470

[ Vapour Pressure ]:
8.18E-07mmHg at 25°C

[ Index of Refraction ]:
1.506

Safety Information

[ HS Code ]:
2922509090

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%