5-Pyrimidineacetic acid, 1,2,3,4-tetrahydro-2,4-dioxo-1-beta-D-ribofur anosyl-, methyl ester

Names

[ Name ]:
5-Pyrimidineacetic acid, 1,2,3,4-tetrahydro-2,4-dioxo-1-beta-D-ribofur anosyl-, methyl ester

[Synonym ]:
uridine 5-acetic acid methyl ester
5-Methoxycarbonylmethyluridine
mcm(5)u
5-Mcmu
methyl 2-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]acetate
5-(2-methoxy-2-oxoethyl)uridine
methyl uridine 5-acetate

Biological Activity

[Description]:

Methyl 1,2,3,4-tetrahydro-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidineacetate is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Melting Point ]:
160-162 °C

[ Molecular Formula ]:
C₁₂H₁₆N₂O₈

[ Molecular Weight ]:
316.26

[ Exact Mass ]:
316.09100

[ PSA ]:
151.34000

[ Storage condition ]:
-20°C