Ranatensin

Names

[ Name ]:
Ranatensin

[Synonym ]:
5-Oxo-L-Pro-L-Val-L-Pro-L-Glu(NH2)-L-Trp-L-Ala-L-Val-Gly-L-His-L-Phe-L-Met-NH2
GLP-VAL-PRO-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2
pGlu-Val-Pro-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2
PYROGLU-VAL-PRO-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2
PGLU-VAL-PRO-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2
PYR-VAL-PRO-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2

Biological Activity

[Description]:

Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212), Bradykinin (HY-P0206), or Norepinephrine (HY-13715)[1][2].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Bombesin Receptor

[In Vitro]

Ranatensin (0.3 nM; 30 min) 能够刺激多种胰促分泌物诱导淀粉酶释放[1]。

[In Vivo]

Ranatesin (10-50 μg/mL, 0.1-1 mL; 静脉注射; 单剂量) 会增加狗和兔子的血压，表明其具有直接的外周血管收缩作用[2]。 Ranatesin (10-50 μg/mL, 0.1-1 mL; 静脉注射; 单剂量) 也能降低猴子的血压，与 Eledoisin (HY-P0006) 一样有效。它对血管平滑肌有直接的外周作用[2]。 Ranatesin (10-50 μg/mL, 0.005-0.1 mL; 静脉注射; 单剂量) 根据大鼠血压的基础水平具有可变的作用，在高水平时显示出降压效果，在低水平时升高血压，产生这一变化的可能原因是外周交感神经末梢释放去甲肾上腺素[2]。

[References]

[1]. Jensen RT, et al. A synthetic peptide that is a bombesin receptor antagonist. Nature. 1984 May 3-9;309(5963):61-3.

[2]. Geller RG, et al. The action of ranatensin, a new polypeptide from amphibian skin, on the blood pressure of experimental animals. Br J Pharmacol. 1970 Dec;40(4):605-16.

Chemical & Physical Properties

[ Density]:
1.326 g/cm3

[ Boiling Point ]:
1790.5ºC at 760 mmHg

[ Molecular Formula ]:
C₆₁H₈₄N₁₆O₁₃S

[ Molecular Weight ]:
1281.48000

[ Flash Point ]:
1036.6ºC

[ Exact Mass ]:
1280.61000

[ PSA ]:
467.26000

[ LogP ]:
3.20430

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.607

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Molecular biology of bombesin-like peptides. Comparison of cDNAs encoding human gastrin-releasing peptide, human neuromedin B, and amphibian ranatensin.

Ann. N. Y. Acad. Sci. 547 , 10-20, (1988)

Bombesin-related peptides induce calcium mobilization in a subset of human small cell lung cancer cell lines.

J. Biol. Chem. 262(34) , 16456-60, (1987)

To examine the biochemical basis for growth factor-induced responses in human lung cancer cells, we used the quin2 technique to study the effect of the amphibian peptide bombesin and its congeners inc...

Identification of the C-terminal amino acid amides by carboxypeptidase Y digestion and fast atom bombardment mass spectrometry.

Biochem. Mol. Biol. Int. 34(5) , 897-907, (1994)

The combination method of carboxypeptidase Y digestion and fast atom bombardment (FAB) mass spectrometry is described for the identification of C-terminal amino acid amides in peptides. Carboxypeptida...