Aflatoxicol

Names

[ Name ]:
Aflatoxicol

[Synonym ]:
ETHYL 4-(4-ISOPROPYLPHENYL)-4-OXOBUTYRATE
aflatoxicol A

Biological Activity

[Description]:

Aflatoxin (Aflatoxin R0) is a metabolite of aflatoxin B1 produced from Rhizopus spp[1], and is mutagenic and carcinogenic mycotoxin[2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Nakazato M, et al. Interconversion of aflatoxin B1 and aflatoxicol by several fungi. Appl Environ Microbiol. 1990 May;56(5):1465-70.

[2]. Carvajal M, et al. Aflatoxin B1 and its interconverting metabolite aflatoxicol in milk: the situation in Mexico. Food Addit Contam. 2003 Nov;20(11):1077-86.

Chemical & Physical Properties

[ Density]:
1.56g/cm3

[ Boiling Point ]:
552.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₁₄O₆

[ Molecular Weight ]:
314.28900

[ Flash Point ]:
210.2ºC

[ Exact Mass ]:
314.07900

[ PSA ]:
78.13000

[ LogP ]:
2.12720

[ Vapour Pressure ]:
5.02E-13mmHg at 25°C

[ Index of Refraction ]:
1.698

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GY1934000

CAS REGISTRY NUMBER :: 29611-03-8

LAST UPDATED :: 199410

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C17-H14-O6

MOLECULAR WEIGHT :: 314.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1092 gm/kg/1Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Reproductive - Tumorigenic effects - testicular tumors

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 20 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 171,79,1986

Safety Information

[ RIDADR ]:
UN 3172

[ Hazard Class ]:
6.1(a)