Br-PEG6-CH2COOtBu

Names

[ CAS No. ]:
297162-48-2

[ Name ]:
Br-PEG6-CH2COOtBu

Biological Activity

[Description]:

Br-PEG6-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₃₅BrO₈

[ Molecular Weight ]:
459.37

Br-PEG6-CH2COOtBu

Names

Biological Activity

Chemical & Physical Properties

Related Compounds