(4R)-2-Undecyl-1,3-thiazolidine-4-carboxylic acid

Names

[ Name ]:
(4R)-2-Undecyl-1,3-thiazolidine-4-carboxylic acid

[Synonym ]:
2-Undecylthiazolidine-4(R)-carboxylic acid
4-Thiazolidinecarboxylic acid, 2-undecyl-, (4R)-
(4R)-2-Undecyl-1,3-thiazolidine-4-carboxylic acid

Biological Activity

[Description]:

CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca2+ in HeLa cells expressing S1P3 receptors[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> LPL Receptor

[Target]

S1PR3

[In Vitro]

BML-241 inhibits increases in intracellular Ca2+ concentration via P2 receptor or α1A-adrenoceptor stimulation and α1A-adrenoceptor-mediated contraction of rat mesenteric artery, while it does not affect S1P3-mediated decrease of Forskolin-induced cyclic AMP accumulation[1].

[References]

[1]. Salvatore Salomone, et al. Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects. Front Pharmacol. 2011 Feb 22;2:9.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
439.2±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₉NO₂S

[ Molecular Weight ]:
287.461

[ Flash Point ]:
219.4±27.3 °C

[ Exact Mass ]:
287.191895

[ PSA ]:
74.63000

[ LogP ]:
5.42

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.495

[ Storage condition ]:
-20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%