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Bax BH3 peptide (55-74), wild type

Names

[ CAS No. ]:
299946-20-6

[ Name ]:
Bax BH3 peptide (55-74), wild type

Biological Activity

[Description]:

Bax BH3 peptide (55-74), wild type is a 20-amino acid Bax BH3 peptide (Bax 1) capable of inducing apoptosis in a variety of cell line models[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[In Vitro]

In addition to disrupting Bax/Bcl-2 and Bax/Bcl-XL, Bax BH3 peptide (55-74), wild type can promote cytochrome c release from isolated mitochondria. Bax BH3 belongs to the Bcl-2 protein family which consists of both pro-apoptotic and anti-apoptotic members. Bax BH3 acts to regulate apoptosis via governance of the 'intrinsic' pathway of cell death[1].

[References]

[1]. Peter E Czabotar, et al. Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. J Biol Chem. 2011 Mar 4;286(9):7123-31.

Chemical & Physical Properties

[ Molecular Formula ]:
C93H163N27O34S2

[ Molecular Weight ]:
2267.60

Related Compounds