Sorbitol dehydrogenase-IN-1

Names

[ CAS No. ]:
300551-49-9

[ Name ]:
Sorbitol dehydrogenase-IN-1

Biological Activity

[Description]:

Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC50 s of 4, 5 nM for rat and human, respectively[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

Sorbitol Dehydrogenase[1]


[In Vivo]

Sorbitol dehydrogenase-IN-1 (compound 16) (50 µg/kg；口服) 在慢性糖尿病大鼠中表现出对坐骨神经果糖的持续抑制作用[1]。

[References]

[1]. Mylari BL, et al. A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol. J Med Chem. 2002 Sep 26;45(20):4398-401.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H25N7O

[ Molecular Weight ]:
343.43

Related Compounds