2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyldihydro-

Names

[ Name ]:
2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyldihydro-

[Synonym ]:
5,5-dideuterio-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-diazinane-2,4-dione
Uridine,5,6-dihydro
Dihydrouridin

Biological Activity

[Description]:

5,6-Dihydro-ara-uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.614g/cm3

[ Molecular Formula ]:
C₉H₁₄N₂O₆

[ Molecular Weight ]:
246.22

[ Exact Mass ]:
246.08500

[ PSA ]:
122.82000

[ Index of Refraction ]:
1.613

2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyldihydro-

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds