Ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl-, N-oxide, hydrochloride (1:1)
Names
[ CAS No. ]:
302-70-5
[ Name ]:
Ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl-, N-oxide, hydrochloride (1:1)
[Synonym ]:
Mitomen
Bis-(2-chlor-aethyl)-hydroxy-methyl-ammonium-chlorid
Oxyamine
N,N-Bis-(2-chlor-aethyl)-N-methyl-hydroxylaminium-chlorid
MBAO hydrochloride
Bis-(2-chlor-aethyl)-methyl-aminoxid,Hydrochlorid
Mustron
N-Oxyd-Lost
mechlorethamine oxide hydrochloride
Nitromin
Ossichlorin
Ossiamina
Nitromin hydrochloride
bis-(2-chloro-ethyl)-methyl-amine oxide,hydrochloride
HN2 oxide hydrochloride
Chemical & Physical Properties
[ Melting Point ]:
-60ºC
[ Molecular Formula ]:
C5H12Cl3NO
[ Molecular Weight ]:
208.51400
[ Exact Mass ]:
206.99800
[ PSA ]:
29.43000
[ LogP ]:
2.23130
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- IA2275000
- CHEMICAL NAME :
- Diethylamine, 2,2'-dichloro-N-methyl-, N-oxide, hydrochloride
- CAS REGISTRY NUMBER :
- 302-70-5
- LAST UPDATED :
- 199510
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C5-H11-Cl2-N-O.Cl-H
- MOLECULAR WEIGHT :
- 208.53
- WISWESSER LINE NOTATION :
- G2KO&1&2G &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 79500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 76100 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 83 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 125 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 4 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes Blood - leukopenia Blood - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Blood - leukopenia Blood - other changes Blood - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Multiple routes
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1300 mg/kg/93W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Blood - leukemia
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA
- TYPE OF TEST :
- Body fluid assay
- TEST SYSTEM :
- Rodent - rat Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 250 mg/kg
- REFERENCE :
- URLRA5 Urological Research. (Springer Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1973- Volume(issue)/page/year: 7,119,1979 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,209,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,209,1975 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987
Safety Information
[ RIDADR ]:
UN 3249
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
[ HS Code ]:
2921199090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921199090
[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%