SARS-CoV-2 3CLpro-IN-6

Names

[ CAS No. ]:
302821-53-0

[ Name ]:
SARS-CoV-2 3CLpro-IN-6

Biological Activity

[Description]:

SARS-CoV-2 3CLpro-IN-6 is a reversible covalent inhibitor of SARS-CoV-2 3CL protease. SARS-CoV-2 3CLpro-IN-6 has potent inhibitory activity for SARS-CoV-2 3CLpro with an IC50 value of 4.9 μM. SARS-CoV-2 3CLpro-IN-6 can be used for the research of coronavirus disease 2019 (COVID-19)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

IC50: 4.9 μM (SARS-CoV-2 3CLpro)[1]


[In Vitro]

SARS-CoV-2 3CLpro-IN-6 (Compound 13) (0-100 μM) has potent inhibitory activity for SARS-CoV-2 3CLpro with IC50 value of 4.9 μM[1]. SARS-CoV-2 3CLpro-IN-6 (5, 10 μM) has typical covalent inhibition behavior with time-dependent activity[1].

[References]

[1]. Liying Wang, et al. Discovery of novel SARS-CoV-2 3CL protease covalent inhibitors using deep learning-based screen. Eur J Med Chem. 2022 Dec 15;244:114803.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H15NO7

[ Molecular Weight ]:
405.36

Related Compounds