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SR 0987

Names

[ CAS No. ]:
303126-97-8

[ Name ]:
SR 0987

[Synonym ]:
2-Chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propanyl)phenyl]benzamide
Benzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-
MFCD02693203

Biological Activity

[Description]:

SR0987 is a RORγt agonist, with an EC50 of 800 nM.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> ROR
Research Areas >> Cancer
Research Areas >> Inflammation/Immunology

[Target]

EC50: 800 nM (RORγt)[1].


[In Vitro]

SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC50 of ~800nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production[1].

[References]

[1]. Chang MR, et al. Synthetic RORγt Agonists Enhance Protective Immunity. ACS Chem Biol. 2016 Apr 15;11(4):1012-8.


[Related Small Molecules]

SR1078 | LYC-55716 | SR3335 | ROR gamma-t-IN-1 | SR1001 | GSK2981278 | SR2211 | Gne-0946 | GNE-6468 | L 601920-0 | RORγ-IN-1 | TMP778

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
378.8±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H10ClF6NO2

[ Molecular Weight ]:
397.699

[ Flash Point ]:
182.9±27.9 °C

[ Exact Mass ]:
397.030426

[ LogP ]:
4.36

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.541

[ Storage condition ]:
2-8℃

Related Compounds