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Dalbergioidin

Names

[ CAS No. ]:
30368-42-4

[ Name ]:
Dalbergioidin

[Synonym ]:
darbergioidin
dalbergioidine
dalbergiodin
4H-1-Benzopyran-4-one, 3-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-
2',4',5,7-tetrahydroxyisoflavanone
3-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydro-4H-chromen-4-one

Biological Activity

[Description]:

Dalbergioidin, a well-known anthocyanin, ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway. Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM[1][2].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad
Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad
Research Areas >> Inflammation/Immunology

[In Vitro]

Dalbergioidin是一种非竞争性抑制剂。此外，DBG在常用作指示生物的海滩链霉菌培养皿中表现出黑色素生物合成的抑制区。

[References]

[1]. Seunghwa Baek, et al. Inhibitory effect of dalbergioidin isolated from the trunk of Lespedeza cyrtobotrya on melanin biosynthesis. J Microbiol Biotechnol. 2008 May;18(5):874-9.  

[2]. Xianguo Ren, et al. Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF- β Signal Pathway. Mediators Inflamm. 2016;2016:5147571.  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
631.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H12O6

[ Molecular Weight ]:
288.25

[ Flash Point ]:
244.4±25.0 °C

[ Exact Mass ]:
288.063385

[ PSA ]:
107.22000

[ LogP ]:
2.51

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.725

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds