2-(Trifluoromethyl)phenylacetic acid

Names

[ Name ]:
2-(Trifluoromethyl)phenylacetic acid

[Synonym ]:
ortho-(trifluoromethyl)phenylacetic acid
EINECS 207-093-9
2-(Trifluoromethyl)benzeneacetic acid
QV1R BXFFF
2-(2'-trifluoromethylphenyl)acetic acid
2-[2-(Trifluoromethyl)phenyl]acetic acid
2-(Trifluoromethyl)phenylacetic acid
MFCD00004327
[2-(Trifluoromethyl)phenyl]acetic acid
(a,a,a-trifluoro-o-tolyl)acetic acid
Benzeneacetic acid, 2-(trifluoromethyl)-
(α,α,α-Trifluoro-o-tolyl)acetic acid
o-(Trifluoromethyl)phenylacetic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
249.9±35.0 °C at 760 mmHg

[ Melting Point ]:
107-110 °C(lit.)

[ Molecular Formula ]:
C₉H₇F₃O₂

[ Molecular Weight ]:
204.146

[ Flash Point ]:
105.0±25.9 °C

[ Exact Mass ]:
204.039810

[ PSA ]:
37.30000

[ LogP ]:
2.08

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.475

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Cyclic RGD peptide analogues as antiplatelet antithrombotics.

J. Med. Chem. 35 , 2040, (1992)

Stimulation of platelets activates GPIIbIIIa, the heterodimeric integrin receptor, to bind fibrinogen (Fg), which results in platelet aggregation. GPIIbIIIa/Fg binding inhibitors are potentially suita...

Effect of structure on potency and selectivity in 2,6-disubstituted 4-(2-arylethenyl)phenol lipoxygenase inhibitors.

J. Med. Chem. 33 , 1892, (1990)

A series of 2,6-disubstituted 4-(2-arylethenyl)phenols with potent human neutrophil 5-lipoxygenase (5-LO) inhibiting activity (IC50S in the 10(-7) M range) and weaker human platelet cyclooxygenase (CO...