Kynuramine Dihydrobromide

Names

[ CAS No. ]:
304-47-2

[ Name ]:
Kynuramine Dihydrobromide

[Synonym ]:
3-(2-Aminophenyl)-3-oxopropanamine
3-amino-1-(2-aminophenyl)propan-1-one,hydrobromide

Biological Activity

[Description]:

Kynuramine (dihydrobromide), an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Metabolic Disease

[In Vitro]

Kynuramine (dihydrobromide) 在体外抑制突触前和突触后 α-肾上腺素受体[2]。 Kynuramine 已被证明是狗脑动脉血清素受体的部分激动剂[2]。 Kynuramine (20 μg/mL) 经常导致回肠轻微收缩，但未能改变胆碱能刺激的抽搐反应[2]。

[In Vivo]

Kynuramine (dihydrobromide) (0.064、0.32、1.6 或 8 μg；脑室内；单剂量) 促进雌激素激发的去卵巢大鼠前凸行为[3]。 Kynuramine (1.25、2.5 和 5.0 mg/kg；静脉注射；单剂量) 可增加大鼠的心率和血压[4]。 Animal Model: Female rats[3]. Dosage: 0.064-8 μg. Administration: Intraventricular injection; single does. Result: Produced facilitation of lordosis behavior. Animal Model: Male rats (about 200g)[4]. Dosage: 1.25-5.0 mg/kg. Administration: Intravenous injection; single does. Result: Promoted heart rate and blood pressure.

[References]

[1]. J B Massey, et al. Kynuramine, a fluorescent substrate and probe of plasma amine oxidase. J Biol Chem. 1977 Nov 25;252(22):8081-4.

[2]. T D Johnson, An alpha-adrenoceptor inhibitory action of kynuramine. Eur J Pharmacol. 1981 Jul 10;72(4):351-6.

[3]. S D Mendelson, et al. Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat. Eur J Pharmacol. 1987 Oct 27;142(3):447-51.

[4]. T D Johnson, et al. Blood pressure and heart rate effects of kynuramine in pithed rats. Eur J Pharmacol. 1983 Feb 18;87(2-3):323-6.

Chemical & Physical Properties

[ Boiling Point ]:
367.3ºC at 760mmHg

[ Molecular Formula ]:
C₉H₁₄Br₂N₂O

[ Molecular Weight ]:
326.02800

[ Flash Point ]:
175.9ºC

[ Exact Mass ]:
323.94700

[ PSA ]:
69.11000

[ LogP ]:
3.99800

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

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Related Compounds

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