BTYNB

Names

[ Name ]:
BTYNB

[Synonym ]:
Benzamide, 2-[[(1E)-(5-bromo-2-thienyl)methylene]amino]-
2-{(E)-[(5-Bromo-2-thienyl)methylene]amino}benzamide
2-{[(E)-(5-bromothiophen-2-yl)methylidene]amino}benzamide
MFCD00977636

Biological Activity

[Description]:

BTYNB is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA with IC50 of 5 uM; has no effect on binding of PR to flPRE; destabilizes c-Myc mRNA, downregulates β-TrCP1 mRNA and reduces activation of NF-κB; also decreases oncogenic translation regulator eEF2 mRNA levels in cancer cells; potently inhibits proliferation of IMP1-containing ovarian cancer and melanoma cells with no effect in IMP1-negative cells.

[References]

References 1. Mahapatra L, et al. Transl Oncol. 2017 Oct;10(5):818-827. View Related Products by Target c-Myc

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
495.9±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₉BrN₂OS

[ Molecular Weight ]:
309.182

[ Flash Point ]:
253.7±27.3 °C

[ Exact Mass ]:
307.961884

[ LogP ]:
2.88

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.685

Safety Information

[ Hazard Codes ]:
Xi