3,6,9,12,15,18,21-Heptaoxatritriacontan-1-ol

Names

[ Name ]:
3,6,9,12,15,18,21-Heptaoxatritriacontan-1-ol

[Synonym ]:
LAURETH-7
HEPTAETHYLENE GLYCOL DODECYL ETHER
3,6,9,12,15,18,21-Heptaoxatritriacontan-1-ol
3,6,9,12,15,18,21-heptaoxatritriacontanol
MFCD00043065
Heptaethylene glycol monododecyl ether
laureth-7 oxyethylene ether
HEPTAETHYLENEGLYCOL-N-DODECYLETHER
EINECS 221-283-9
dodecylalcohol heptaethoxylate
C12E7
POLYOXYETHYLENE 7 LAURYL ETHER
20-dodecyloxy-3,6,9,12,15,18-hexaoxa-eicosan-1-ol
HEPTAOXYETHYLENE MONO-N-DODECYL ETHER

Biological Activity

[Description]:

Dodecylheptaglycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
553.9±45.0 °C at 760 mmHg

[ Melting Point ]:
27-29 °C

[ Molecular Formula ]:
C₂₆H₅₄O₈

[ Molecular Weight ]:
494.702

[ Flash Point ]:
288.8±28.7 °C

[ Exact Mass ]:
494.381866

[ PSA ]:
84.84000

[ LogP ]:
2.90

[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C

[ Index of Refraction ]:
1.458

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Y. Ichikawa et al.

J. Ferment. Technol. 56 , 403, (1978)