3,3'-Diethyl-9-methylthiacarbocyanine iodide

Names

[ Name ]:
3,3'-Diethyl-9-methylthiacarbocyanine iodide

[Synonym ]:
3,3′-Diethyl-9-methylthiacarbocyanine iodide
Benzothiazolium,3-ethyl-2-(3-(3-ethyl-2(3H)-benzothiazolylidene)-2-methyl-1-propenyl)-,iodide
3-ethyl-2-[3-(3-ethyl-3H-benzothiazol-2-ylidene)-2-methyl-propenyl]-benzothiazolium,iodide
1,3-Bis-(3-aethyl-benzothiazol-2-yl)-2-methyl-trimethinium,Jodid
MFCD00011955
3,3'-Diethyl-9-methylthiocarbocyanin Iodid (11b)
Benzothiazolium,3-ethyl-2-(3-(3-ethyl-2-benzothiazolinylidene)-2-methyl-1-propenyl)-,iodide
1,3-bis-(3-ethyl-benzothiazol-2-yl)-2-methyl-trimethinium,iodide
3,3'-Diethyl-9-methylthiacarbocyanine iodide
T0500-8750
3-Ethyl-2-(3-(3-ethyl-3H-benzothiazol-2-ylidene)-2-methylprop-1-enyl)benzothiazolium iodide
3-ethyl-2-[3-(3-ethyl-3H-2-benzothiazolylidene)-2-methyl-1-propenyl] benzothiazolium iodide
EINECS 221-317-2

Biological Activity

[Description]:

3,3'-Diethyl-9-methylthiacarbocyanine iodide is a cyanine dye, also a tau aggregation inhibitor, with an IC50 value of 0.28 μM for tau. 3,3'-Diethyl-9-methylthiacarbocyanine iodide can cause misfunction of the microtubule cytoskeleton. 3,3'-Diethyl-9-methylthiacarbocyanine iodide can be used for researching Alzheimer’s disease[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

Research Areas >> Neurological Disease

[Target]

IC50: 0.28 μM (tau)[1]

[References]

[1]. Chang E, et al. Structure-activity relationship of cyanine tau aggregation inhibitors. J Med Chem. 2009 Jun 11;52(11):3539-47.

Chemical & Physical Properties

[ Melting Point ]:
290ºC(dec.)(lit.)

[ Molecular Formula ]:
C₂₂H₂₃IN₂S₂

[ Molecular Weight ]:
506.46600

[ Exact Mass ]:
506.03500

[ PSA ]:
65.29000

[ LogP ]:
2.41390

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL7047000

CHEMICAL NAME :: Benzothiazolium, 3-ethyl-2-(3-(3-ethyl-2-benzothiazolinylidene)-2-meth yl-1-propenyl)-, iodide

CAS REGISTRY NUMBER :: 3065-79-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H23-N2-S2.I

MOLECULAR WEIGHT :: 506.49

WISWESSER LINE NOTATION :: T56 BNYSJ B2 CU2U1- CT56 BK DSJ B2 G1 &I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03432

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S36

[ WGK Germany ]:
3

[ RTECS ]:
DL7047000