L-Theanine

Names

[ Name ]:
L-Theanine

[Synonym ]:
L-Theanine
THEANINE,L
(5Z)-5-(Ethylimino)-5-hydroxy-L-norvaline
Nγ-Ethyl-L-glutamine
N5-ethylglutamine
L-Glutamic acid γ-(ethylamide)
N(5)-ethyl-L-glutamine zwitterion
Theanine
(2S)-2-amino-4-(ethylcarbamoyl)butanoic acid
N-γ-ethyl-L-glutamine
L-TheaMine
L-Glutamine, N-ethyl-
SUNTHEANINE
EINECS 221-379-0
MFCD00059653
L-Norvaline, 5-(ethylimino)-5-hydroxy-, (5Z)-
N5-Ethyl-L-glutamine
(S)-2-Amino-5-(ethylamino)-5-oxopentanoic acid
N'-Ethyl-L-glutamine
N(5)-ethyl-L-glutamine
N-Ethyl-L-glutamine
L-γ-Glutamylethylamide

Biological Activity

[Description]:

L-Theanine (L-Glutamic Acid γ-ethyl amide）is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective and anti-oxidative activities. L-Theanine causes anti-stress effects via the inhibition of cortical neuron excitation by oral intake[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Vuong QV, et al. L-Theanine: properties, synthesis and isolation from tea. J Sci Food Agric. 2011 Aug 30;91(11):1931-9.

[2]. Kimura K, et al. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39-45.

[3]. Takeshima M, et al. l-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes. J Clin Biochem Nutr. 2016 Sep;59(2):93-99.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
430.2±40.0 °C at 760 mmHg

[ Melting Point ]:
207°C

[ Molecular Formula ]:
C₇H₁₄N₂O₃

[ Molecular Weight ]:
174.198

[ Flash Point ]:
214.0±27.3 °C

[ Exact Mass ]:
174.100449

[ PSA ]:
92.42000

[ LogP ]:
-1.02

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.492

[ Storage condition ]:
Store at?0-5°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317

[ Precautionary Statements ]:
P280

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R43

[ Safety Phrases ]:
S28-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%