NS383

Names

[ Name ]:
NS383

[Synonym ]:
8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime
1H-Pyrrolo[3,2-h]isoquinolin-2-ol, 8-ethyl-6,7,8,9-tetrahydro-3-nitroso-5-phenyl-
8-Ethyl-3-nitroso-5-phenyl-6,7,8,9-tetrahydro-1H-pyrrolo[3,2-h]isoquinolin-2-ol

Biological Activity

[Description]:

NS383 is a potent and uniquely selective inhibitor of rat ASICs containing 1a and/or 3 subunits. NS383 inhibits H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC50 values ranging from 0.61 to 2.2 μM. NS383 is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Neurological Disease

[References]

[1]. Munro G, et al. NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats. CNS Neurosci Ther. 2016;22(2):135-145.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
583.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₉N₃O₂

[ Molecular Weight ]:
321.37

[ Flash Point ]:
306.5±30.1 °C

[ Exact Mass ]:
321.147736

[ LogP ]:
3.93

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.694