ABC-1

ABC-1 is a phosphorylated analogue and a potential antiviral agent against Newcastle disease virus (NDV). ABC-1 has potent antiviral activity[1][2].

Research Areas >> Infection

Signaling Pathways >> Others >> Others

ABC-1 (175 and 350 μM; 96 hours) potently inhibits Cytopathic effect (CPE) [1]. Cell Cytotoxicity Assay[1] Cell Line: DF-1 cells Concentration: 175 and 350 μM Incubation Time: 96 hours Result: Inhibits Cytopathic effect (CPE).

ABC-1 (2 mg/kg; Oral) reduces colocalized cells in liver and clara cells in lung tissue when compared to NDV control animals[2]. Animal Model: Chickens (NDV treated) [2] Dosage: 2 mg/kg Administration: Oral Result: Reduced colocalized cells in liver and clara cells in lung tissue when compared to NDV control animals.

[1]. K A S, et al. Design, Synthesis and Biological Evaluation of Novel Phosphorylated Abacavir Derivatives as Antiviral Agents Against Newcastle Disease Virus Infection in Chicken. Appl Biochem Biotechnol. 2016;180(2):361-381.

[2]. Suresh KA, et al. Phosphorylated abacavir analogue (ABC-1) has ameliorative action against Newcastle disease virus induced pathogenesis in chicken. Biotechnol Appl Biochem. 2019;66(6):977-989.