3,5-Difluorophenylalanine

Names

[ Name ]:
3,5-Difluorophenylalanine

[Synonym ]:
2(S)-Amino-3-(3,5-difluorophenyl)-propionic acid
1(S)-2-amino-3-(3,5-difluorophenyl)propanoic acid
(S)-3,5-difluoro-phenylalanine
(2S)-2-Amino-3-(3,5-difluorophenyl)propionic acid
Phenylalanine, 3,5-difluoro-
3,5-Difluorophenylalanine
3-(3,5-Difluorophenyl)-L-alanine
MFCD01631987
(S)-2-Amino-3-(3,5-difluoro-phenyl)-propionic acid
L-3,5-Difluorophenylalanine
3,5-difluoro-l-phenylalanine
L-3,5-DIFLUOROPHE
3',5'-Difluoro-L-phenylalanine
H-Phe(3,5-DiF)-OH
(S)-2-Amino-3-(3,5-difluorophenyl)propanoic acid
(2S)-2-amino-3-(3,5-difluorophenyl)propanoic acid
L-Phenylalanine, 3,5-difluoro-
DL-3,5-Difluoro-phe-OH
(S)-2-Amino-3-(3,5-difluorophenyl)propionic acid

Biological Activity

[Description]:

H-Phe(3,5-DiF)-OH is a difluorophenylalanines in the L-configuration [L-(F2)Phe]. H-Phe(3,5-DiF)-OH can be incorporated into the thrombin receptor-tethered ligand peptide SFLLRNP to identify the phenyl hydrogens of the Phe-2 residue involved in the CH/π receptor interaction[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Fujita T, et al. Synthesis of a complete set of l-difluorophenylalanines, l-(F2)Phe, as molecular explorers for the CH/π interaction between peptide ligand and receptor. Tetrahedron Letters. 2000, 41(6):923-927.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
295.1±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₉F₂NO₂

[ Molecular Weight ]:
201.170

[ Flash Point ]:
132.3±27.3 °C

[ Exact Mass ]:
201.060135

[ PSA ]:
63.32000

[ LogP ]:
1.25

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.536

[ Storage condition ]:
Store at 0-5°C

MSDS

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Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S37/39-S26

[ RTECS ]:
UH0420000

[ HS Code ]:
2922499990

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%