Tsar

Names

[ Name ]:
Tsar

[Synonym ]:
1-methylethyl (2E)-3-[[(ethylamino)methoxyphosphinothioyl]oxy]-2-butenoate
Propetamphos [BAN]
PROPETAMPHOS
Safrotin S 200
Deadmag
(E)-3-Hydroxycrotonic Acid Isopropyl Ester O-Ester with o-Methyl Ethylphosphoramidothioate
2-Butenoic acid, 3-[[(ethylamino)methoxyphosphinothioyl]oxy]-, 1-methylethyl ester, (2E)-
Seraphos
propan-2-yl (2E)-3-{[(ethylamino)(methoxy)phosphorothioyl]oxy}but-2-enoate
Isopropyl-(2E)-3-{[(ethylamino)(methoxy)phosphorothioyl]oxy}but-2-enoat
propan-2-yl (E)-3-[ethylamino(methoxy)phosphinothioyl]oxybut-2-enoate
EINECS 250-517-2
1-methylethyl (2E)-3-{[(ethylamino)(methoxy)phosphorothioyl]oxy}but-2-enoate
Isopropyl 3-(ethylamino(methoxy)phosphinothioyloxy)isocrotonate
PS1076_SUPELCO
propan-2-yl (2E)-3-{[(Ξ)-N-ethyl-P-methoxyphosphoramidothioyl]oxy}but-2-enoate
Blotic
(E)-1-Methylethyl 3-[[(Ethylamino)methoxyphosphinothioyl]oxy]-2-butenoate
(E)-O-2-Isopropoxycarbonyl-1-methylvinyl O-Methyl Ethylphosphoramidothioate
MFCD00137384
Isopropyl (2E)-3-{[(ethylamino)(methoxy)phosphorothioyl]oxy}but-2-enoate
Tsar
2-Butenoic acid, 3-(((ethylamino)methoxyphosphinothioyl)oxy)-, 1-methylethyl ester, (E)-
Isopropyl (2E)-3-{[(ethylamino)(methoxy)phosphorothioyl]oxy}-2-butenoate
SAN 322I
(RS)-[(E)-O-2-isopropoxycarbonyl-1-methylvinyl O-methyl ethylphosphoramidothioate]

Biological Activity

[Description]:

Propetamphos is an organophosphorus insecticide. Propetamphos causes cytotoxicity and oxidative stress[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[In Vivo]

Propolis (100 mg/kg/天；口服；28 天) 对由 Propetamphos 诱导的 Wistar Albino 大鼠表现出抗自由基和抗氧化作用[1]。

[References]

[1]. Kanbur M, et al. Antioxidant effect of propolis against exposure to propetamphos in rats. Ecotoxicol Environ Saf. 2009 Mar;72(3):909-15.

[2]. Cetin E, et al. Propetamphos-induced changes in haematological and biochemical parameters of female rats: protective role of propolis. Food Chem Toxicol. 2010 Jul;48(7):1806-10.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
321.1±44.0 °C at 760 mmHg

[ Melting Point ]:
<25℃

[ Molecular Formula ]:
C₁₀H₂₀NO₄PS

[ Molecular Weight ]:
281.31

[ Flash Point ]:
148.0±28.4 °C

[ Exact Mass ]:
281.085052

[ PSA ]:
98.69000

[ LogP ]:
1.61

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.495

[ Storage condition ]:
APPROX 4°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GQ4750000

CHEMICAL NAME :: Crotonic acid, 3-hydroxy-, isopropyl ester, O-ester with O-methyl ethylphosphoramidothioate, (E)-

CAS REGISTRY NUMBER :: 31218-83-4

LAST UPDATED :: 199706

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H20-N-O4-P-S

MOLECULAR WEIGHT :: 281.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 62400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 37,1621,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 564 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 35,1315,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 49 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 34,79,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSTDAN Pesticides. (Colour Pub. Pvt. Ltd., 126-A Dhuruwadi, Off Dr. Nariman Rd., Bombay 400-025, India) V.1- 1967- Volume(issue)/page/year: 15(10),37,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSTDAN Pesticides. (Colour Pub. Pvt. Ltd., 126-A Dhuruwadi, Off Dr. Nariman Rd., Bombay 400-025, India) V.1- 1967- Volume(issue)/page/year: 15(10),37,1981 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2243 No. of Facilities: 6 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 6 (estimated)

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311-H330-H410

[ Precautionary Statements ]:
P260-P273-P280-P284-P301 + P310 + P330-P304 + P340 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T: Toxic;N: Dangerous for the environment;

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
S37;S45;S60;S61

[ RIDADR ]:
UN 3018

[ RTECS ]:
GQ4750000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2931900090

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

Articles

Activated transformations of organophosphorus insecticides in the case of non-AChE inhibitory oxons.

Pest Manag. Sci. 58(11) , 1107-17, (2002)

Many organophosphorus (OP) compounds are of the thiono form and in insects or animals are converted by microsomal mixed function oxidases (MFO) into the oxon forms which inhibit acetylcholinesterase (...

Insecticide susceptibility of cat flea (Siphonaptera: Pulicidae) pupae.

J. Econ. Entomol. 89(2) , 421-7, (1996)

Studies were conducted to investigate what protective nature the cocoon and nylon carpeting has against the performance of insecticides directed at cat flea, Ctenocephalides felis (Bouché), pupae deve...

Survey of levels of propetamphos and diazinon used to control sheep scab in Northern Ireland.

Vet. Rec. 126(11) , 263-5, (1990)

As a result of an increase in the incidence of sheep scab in Northern Ireland, the concentrations of propetamphos and diazinon were measured during 1987 and 1988 in fleece and liquid dip samples from ...