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PD 118057

Names

[ CAS No. ]:
313674-97-4

[ Name ]:
PD 118057

[Synonym ]:
2-[[4-[2-(3,4-Dichlorophenyl)ethyl]phenyl]amino]benzoic acid

Biological Activity

[Description]:

PD-118057 is a human ether-a-go-go-related gene (hERG) channel activator that does not cause hERG blockade[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

Human ether-a-go-go-related gene channel[1]


[References]

[1]. Mao H, et al. Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin. PLoS One. 2013 Jun 19;8(6):e65481.

Chemical & Physical Properties

[ Density]:
1.353g/cm3

[ Boiling Point ]:
527ºC at 760 mmHg

[ Molecular Formula ]:
C21H17Cl2NO2

[ Molecular Weight ]:
386.27

[ Flash Point ]:
272.52ºC

[ Exact Mass ]:
385.06400

[ PSA ]:
49.33000

[ LogP ]:
6.29340

[ Index of Refraction ]:
1.668

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H413

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport


Related Compounds