DSHN

Names

[ Name ]:
DSHN

[Synonym ]:
5-[(Diethylamino)sulfonyl]-3-hydroxy-2-naphthalenecarboxylic acid
DSHN
2-Naphthalenecarboxylic acid, 5-[(diethylamino)sulfonyl]-3-hydroxy-
5-(diethylsulfamoyl)-3-hydroxy-2-naphthalenecarboxylic acid
5-(Diethylsulfamoyl)-3-hydroxy-2-naphthoic acid
5-(DIETHYLSULFAMOYL)-3-HYDROXYNAPHTHALENE-2-CARBOXYLIC ACID

Biological Activity

[Description]:

DSHN is a potent small heterodimer partner (SHP) activator. DSHN inhibits Ccl2 expression and secretion by inhibiting p65 activation of Ccl2 promoter activity. DSHN can be used in research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Yang Z, et, al. A Novel Small Molecule Activator of Nuclear Receptor SHP Inhibits HCC Cell Migration via Suppressing Ccl2. Mol Cancer Ther. 2016 Oct;15(10):2294-2301.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
519.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₇NO₅S

[ Molecular Weight ]:
323.36

[ Flash Point ]:
268.1±32.9 °C

[ Exact Mass ]:
323.082733

[ LogP ]:
3.49

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.634