Bromacil

Names

[ CAS No. ]:
314-40-9

[ Name ]:
Bromacil

[Synonym ]:
5-Bromo-3-(sec-butyl)-6-methylpyrimidine-2,4(1H,3H)-dione
5-bromo-3-(butan-2-yl)-6-methylpyrimidine-2,4(1H,3H)-dione
Uragon
2,4(1H,3H)-Pyrimidinedione, 5-bromo-6-methyl-3-(1-methylpropyl)-
Urox B
hibor
EINECS 206-245-1
5-Br
5-Brom-3-(butan-2-yl)-6-methylpyrimidin-2,4(1H,3H)-dion
5-Bromo-3-sec-butyl-6-methyl-2,4(1H,3H)-pyrimidinedione
(RS)-5-bromo-3-sec-butyl-6-methyluracil
Nalkil
Borea
5-bromo-6-methyl-3-(1-methylpropyl)-2,4(1H,3H)-pyrimidinedione
5-bromo-3-s-butyl-6-methyluracil
Rout
Bromax
5-Bromo-3-sec.-butyl-6-methyluracil
5-Brom-3-sec-butyl-6-methylpyrimidin-2,4(1H,3H)-dion
5-Bromo-3-sec-butyl-6-methyluracil
5-Bromo-3-sec-butyl-6-methylpyrimidine-2,4(1H,3H)-dione
rac-(3R)-5-bromo-3-(butan-2-yl)-6-methylpyrimidine-2,4(1H,3H)-dione
T6MVNVJ CY2&1 EE F1
MFCD00055364
Bromacil
Hyvar
5-bromo-6-methyl-3-(1-methylpropyl)pyrimidine-2,4(1H,3H)-dione

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
411ºC

[ Melting Point ]:
157-160°C

[ Molecular Formula ]:
C₉H₁₃BrN₂O₂

[ Molecular Weight ]:
261.116

[ Exact Mass ]:
260.016022

[ PSA ]:
54.86000

[ LogP ]:
2.10

[ Index of Refraction ]:
1.541

[ Stability ]:
Stable. Incompatible with strong acids, strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ9100000

CHEMICAL NAME :: Uracil, 5-bromo-3-sec-butyl-6-methyl-

CAS REGISTRY NUMBER :: 314-40-9

BEILSTEIN REFERENCE NO. :: 0647896

LAST UPDATED :: 199712

DATA ITEMS CITED :: 34

MOLECULAR FORMULA :: C9-H13-Br-N2-O2

MOLECULAR WEIGHT :: 261.15

WISWESSER LINE NOTATION :: T6MVNVJ CY2&1 EE F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 641 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4800 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3040 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10350 mg/kg/2W-I

TOXIC EFFECTS :: Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 45625 mg/kg/2Y-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 38 mg/m3/2H

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB84-138973 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1 ppm (10 mg/m3) JAN 1993 OEL-BELGIUM:TWA 1 ppm (11 mg/m3) JAN 1993 OEL-DENMARK:TWA 5 mg/m3 JAN 1993 OEL-FINLAND:TWA 1 ppm (10 mg/m3);STEL 3 ppm (30 mg/m3) JAN 1993 OEL-FRANCE:TWA 1 ppm (10 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 1 ppm (10 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 1 ppm (10 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 1 ppm (10 mg/m3);STEL 2 ppm (20 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO BROMACIL-air:10H TWA 1 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80830 No. of Facilities: 362 (estimated) No. of Industries: 11 No. of Occupations: 5 No. of Employees: 1905 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80830 No. of Facilities: 755 (estimated) No. of Industries: 7 No. of Occupations: 6 No. of Employees: 4372 (estimated) No. of Female Employees: 63 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335-H400

[ Precautionary Statements ]:
P261-P273-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;N: Dangerous for the environment;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S26-S61

[ RIDADR ]:
UN3077 9/PG 3

[ RTECS ]:
YQ9100000

[ HS Code ]:
2933599014

Customs

[ HS Code ]: 2933599014

[ Summary ]:
2933599014 6-nitroso-7h-purine。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

Articles

Toxicity of the herbicides bromacil and simazine to the aquatic macrophyte, Vallisneria americana Michx.

Environ. Toxicol. Chem. 29(1) , 201-11, (2010)

Vallisneria americana Michx. (tapegrass) is an ecologically important submersed, vascular aquatic plant that provides food and shelter for many aquatic and waterfowl species. This plant often occurs c...

Determination of selected herbicides and phenols in water and soils by solid-phase extraction and high-performance liquid chromatography.

J. Chromatogr. Sci. 38(5) , 211-8, (2000)

A high-performance liquid chromatography procedure or the determination of the herbicides simazine, propazine, bromacil, metoxuron, and hexazinone is elaborated. Stationary phases RP8 and RP18 and mix...

Combined photobacterium toxicity of herbicide mixtures containing one insecticide.

Chemosphere 75(3) , 381-8, (2009)

To test whether the dose-addition (DA) model can predict the combined toxicity of the mixtures of herbicides that coexisted with insecticide(s), we selected five herbicides (simetryn, prometon, bromac...