m-PEG3-SH

Names

[ CAS No. ]:
31521-83-2

[ Name ]:
m-PEG3-SH

[Synonym ]:
3,6,9-trioxadecanoic acid
1-mercapto-4,7,10-trioxaundecane

Biological Activity

[Description]:

m-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.017

[ Molecular Formula ]:
C₇H₁₆O₃S

[ Molecular Weight ]:
180.26500

[ Exact Mass ]:
180.08200

[ PSA ]:
66.49000

[ LogP ]:
1.28780

Safety Information

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%