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ICA-105574

Names

[ CAS No. ]:
316146-57-3

[ Name ]:
ICA-105574

[Synonym ]:
3-nitro-N-(4-phenoxyphenyl)-benzamide
3-NITRO-N-(4-PHENOXYPHENYL)BENZAMIDE
F1107-0308

Biological Activity

[Description]:

ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Gerlach AC, et al. Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574). Mol Pharmacol. 2010;77(1):58-68.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H14N2O4

[ Molecular Weight ]:
334.33

[ Exact Mass ]:
334.09500

[ PSA ]:
84.15000

[ LogP ]:
5.23560

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317-H319-H400

[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338

[ RIDADR ]:
UN 3077 9 / PGIII

Related Compounds